PHASE-I EVALUATION OF A WEEKLY SCHEDULE OF ANGUIDINE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 63  (11-1) , 2015-2017
Abstract
A phase I evaluation of a weekly schedule of anguidine was undertaken as an alternative to the present continuous daily schedules. The dose ranged from 1.5-7.5 mg/m2 given as an infusion over 3 h. No myelosuppression was noted at any dose level. The toxic effects included nausea and vomiting, hypotension, CNS symptoms (confusion, hallucinations and psychomoter seizures), chills, fever and diarrhea. A dose of 5 mg/m2 of anguidine produced acceptable toxicity.

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