The effect of dietary protein deprivation on protein synthesis in the isolated liver parenchymal cell

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Abstract
1. Parenchymal cells were isolated from the liver of rats that had been deprived of dietary protein for 3 weeks.2. The cells were two-thirds the diameter of those derived from livers of normal animals and consumed oxygen at a rate of 16.2±2.7 μl/h per 106viable cells, half the normal value.3. Albumin and transferrin were synthesized at rates of 0.94±0.12 and 0.60±0.07 μg/h per 106viable cells respectively and urea at a rate of 0.77±0.12 μg/h per 106cells. This represents a 25-50% decrease in the rates of synthesis measured in cells isolated from normal livers.4. The results are discussed in relation to the long-term effects of malnutrition on liver cell function.