Increased cell proliferation and associated expression of PDGFRβ causing hypercellularity in patellar tendinosis

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Abstract
Objective. This study assessed cellularity in patellar tendinosis with respect to cell proliferation and the expression of platelet‐derived growth factor receptor β (PDGFRβ). Methods. Surgical samples were taken from 11 patients fulfilling criteria of patellar tendinosis and from 12 matched controls. Standard immunohistochemistry methods were used to detect expression of PDGFRβ and proliferation cell nuclear antigen (PCNA). Results were analysed by computer‐assisted microscopy. Tendon cells were isolated from nine tendinosis and eight control tissues for cell culture. Results. Increased cellularity (PPβ was demonstrated (PPPPConclusion. Hypercellularity in patellar tendinosis is caused by increased cell proliferation and is associated with increased expression of PDGFRβ.