Amino Acids and Peptides; 67.1Easy Preparation and Use of Benzyloxycarbonyl Derivatives of Amino Acid Chlorides and α-Hydroxycarboxylic Acid Chlorides
- 1 January 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1988 (06) , 475-477
- https://doi.org/10.1055/s-1988-27612
Abstract
N-Benzyloxycarbonyl amino acid chlorides and α-benzyloxycarbonyloxy carboxylic acid chlorides are readily available by treating the corresponding carboxylic acids with 1-chloro-N,N,2-trimethyl-1-propen-1-amine. They can be immediately reacted with O-, N- and C-nucleophiles to afford peptides, ketones and esters.Keywords
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