Human "Analgesic" Action of d-Amphetamine, Amobarbital, Acetylsalicylic Acid and Acetophenetidin, in Combination
- 1 July 1953
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 83 (3) , 515-518
- https://doi.org/10.3181/00379727-83-20401
Abstract
Summary Four treatments were compared on each of 16 human subjects for their ability to elevate the threshold to experimentally induced pain of the tooth pulp, by the method and discipline of Harris and Blockus. Rigorous elimination of bias was exercised. The treatments were: A. d-amphetamine, 5 mg; amobarbital, 32 mg; acetylsalicylic acid, 162 mg; acetophenetidin, 162 mg; B. acetylsalicylic acid, 162 mg; acetophenetidin, 162 mg; C. placebo; D. no medication, i.e., a dry-run. The threshold of experimentally induced pain was elevated more significantly during the 2y2 hours after the amphetamine mixture than after the other 3 treatments.Keywords
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