Potentiation of Radiation Effects in Hypoxic HeLa Cells

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Abstract
HeLa human cervical cancer cells were irradiated with 2 doses of .gamma.-rays: the 1st dose was delivered under hypoxic conditions and the 2nd dose was delivered under oxygenated conditions. Increased inactivation of cellular proliferative capacity as a function of intervening time was obtained when hypoxic conditions were maintained between doses. Hypoxic protection from ionizing irradiation can be counteracted by manipulating postirradiation conditions.