Prediction of creatinine clearance from serum creatinine concentration based on lean body mass

Publisher Website
Google Scholar
Abstract
An equation for predicting endogenous creatinine clearance (CrCl) in adults and children (with both stable and unstable renal function) from serum creatinine concentrations is presented. The predictions are compared with 4 other available estimating methods, based on values in 110 subjects with renal impairment of widely differing degrees. In patients with stable and with unstable renal function the correlation between measured and predicted CrCl was better with the new equation. In patients with rapidly changing renal function the new equation caused accurate predictions of CrCl within a few hours after the change, as opposed to several days with the other methods. The elimination rate constant of the aminoglycoside antibiotic amikacin correlated more precisely with CrCl values estimated from the new equation than with those measured during 24 h or with the other prediction methods.