Some pharmacokinetical aspects of ampicillin trihydrate and its therapeutic efficacy in experimentalescherichia coliinfection in poultry

1 January 1981

journal article
research article
Published by Taylor & Francis in Avian Pathology

Vol. 10 (1) , 43-55
https://doi.org/10.1080/03079458108418457

Abstract

Pharmacokinetical studies of ampicillin trihydrate indicate rapid absorption and very fast elimination in poultry. No significant differences in pharmacokinetical properties of this drug were demonstrated between different hybrids of various ages or between E. coli-infected and normal broilers. The drug could not be detected in the blood plasma during medication with the conventional dose of 55 mg/l in the drinking water. An increase of the dose 10- to 50-fold resulted in average plasma concentrations of .ltoreq. 1 .mu.g/ml (variation < 0.1 - 2.6 .mu.g/ml). In efficacy trials using an infection model with an E. coli strain with a minimal inhibitory concentration (M.I.C.) of 3.2 .mu.g/ml, a good therapeutic effect was observed when ampicillin trihydrate was given for 4 days at a concentration in the drinking water of at least 1.65 g/1.

Keywords

This publication has 1 reference indexed in Scilit:

Observations on experimental infection of chicks withescherichia coli
Avian Pathology, 1978