Appearance of a New Nucleosomal Protein During Differentiation of Human Leukemia (HL-60) Cells
- 30 March 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 223 (4643) , 1420-1423
- https://doi.org/10.1126/science.6583846
Abstract
A 60-kilodalton protein was identified in chromatin digested by micrococcal nuclease during retinoic acid-induced differentiation of human leukemia (HL-60) cells to mature-like granulocytes. The protein was not detected in a retinoic acid-resistant variant of the HL-60 cell line treated with retinoic acid, in HL-60 cells induced with dimethyl sulfoxide, or in normal human granulocytes. This protein may have an important role in the regulation of retinoic acid-induced leukemic cell differentiation.This publication has 15 references indexed in Scilit:
- Histone-dependent reconstitution and nucleosomal localization of a nonhistone chromosomal protein: the H2A-specific proteaseBiochemistry, 1982
- Detection of a histone‐2a related polypeptide in differentiated human myeloid cells (hl‐60) and its distribution in human acute leukemiaInternational Journal of Cancer, 1981
- Two-dimensional hybridization mapping of nucleosomesJournal of Molecular Biology, 1981
- Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide.The Journal of Experimental Medicine, 1979
- Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemiaNature, 1978
- ChromatinNature, 1978
- Continuous growth and differentiation of human myeloid leukaemic cells in suspension cultureNature, 1977
- Heterogeneity of chromatin subunits in vitro and location of histone H1.Nucleic Acids Research, 1976
- Chromatin Structure: A Repeating Unit of Histones and DNAScience, 1974
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970