Innate immune recognition of viral infection
Top Cited Papers
- 19 January 2006
- journal article
- review article
- Published by Springer Nature in Nature Immunology
- Vol. 7 (2) , 131-137
- https://doi.org/10.1038/ni1303
Abstract
Induction of the antiviral innate immune response depends on recognition of viral components by host pattern-recognition receptors. Members of the Toll-like receptor family have emerged as key sensors that recognize viral components such as nucleic acids. Toll-like receptor signaling results in the production of type I interferon and inflammatory cytokines and leads to dendritic cell maturation and establishment of antiviral immunity. Cells also express cytoplasmic RNA helicases that function as alternative pattern-recognition receptors through recognition of double-stranded RNA produced during virus replication. These two classes of pattern-recognition receptor molecules are expressed in different intracellular compartments and induce type I interferon responses via distinct signaling pathways.Keywords
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