Molecular events in the processing of avidin by antigen-presenting cells (APC)
- 1 January 1983
- journal article
- research article
- Published by Springer Nature in Immunogenetics
- Vol. 18 (3) , 267-275
- https://doi.org/10.1007/bf00952965
Abstract
The immune response of T lymphocytes to avidin was measured by proliferative assays, antibody production and delayed-type hypersensitivity. Mice ofH-2k haplotypes were found to be low responders, whereas mice of other haplotypes, and particularly ofH-2 s , were high responders.Ir genes controlling this response were mapped to theI subregion ofH-2. Helper T cells were found to be responsible for the Ir phenotype of antibody production. These results indicate the feasibility of using the avidin-biotin complex as a tool for studying molecular mechanisms by which antigens underIr gene control are processed and presented to T lymphocytes.Keywords
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