Vasopressin effects on isolated non‐pregnant myometrium and uterine arteries and their inhibition by deamino‐ethyl‐lysine‐vasopressin and deamino‐ethyl‐oxytocin

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Abstract
Summary. The contractile effects of lysine‐ (L) and arginine‐ (A) vasopressin (VP) on isolated non‐pregnant myometrium and uterine arteries and the inhibition of these actions by two analogues of posterior pituitary hormones, deamino‐ethyl‐LVP (dE‐LVP) and deamino‐ethyl‐oxytocin (dE‐OXY) were investigated. Both AVP and LVP effectively stimulated the smooth muscle preparations. The threshold dose for both agonists was about 2 ng/ml of bath fluid and a maximal response was obtained with approximately 75 ng/ml. No distinguishable effect was produced by dE‐LVP and dE‐OXY alone, but when given before the agonists in concentrations of 150 or 300 ng/ml, dose‐dependent inhibition of the contractions was seen. The inhibition of the uterine artery responses was always greater than the inhibition of the effects on myometrial activity and dE‐LVP appeared to have stronger antagonistic effects than dE‐OXY on the myometrial responses to the agonists. The inhibition of the myometrial and uterine artery responses to AVP could explain the therapeutic effect of dE‐OXY recently found in primary dysmenorrhoea, where increased VP secretion seems to be of aetiological importance.

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