Effect of Neurotomy on Hexokinase and Phosphorylase Activities of Rat Muscle

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Abstract
Following denervation the hexokinase activity of the muscle increased and remained high for the duration of the time period studied. The bearing of these results, which were obtained in vitro, on the utilization of blood glucose in the living muscle, is discussed. The synthetic activity of muscle phosphorylase is significantly increased at least for the first 10 days postoperatively, but its phosphorolytic activity decreased as atrophy of the muscle progressed. There was no significant difference in phosphorylase activity when it was estimated in N2 or in air. Evidently the effect of neurotomy on the phosphorylase activity is very similar to that of starvation. The significance of the results obtained in this study is discussed in terms of their possible bearing on current theories of mechanism of muscular atrophy.

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