The relation existing between anemia and various gastric affections has been a matter of great interest for many years. As early as 1860, Austin Flint1called attention to the possible dependence of certain cases of pernicious anemia on certain degenerative changes in the gastric mucosa. In 1865, Samuel Fenwick2published a memoir on "Morbid Changes in the Stomach and Intestinal Villi Present in Persons Who Have Died of Cancer" in which he observed the disappearance of the cells in the gastric tubules, granular and fatty degeneration and atrophy, and an increased formation of connective tissue with a marked thinning of the mucous membrane, and with loss of flesh. Especially did this condition occur in persons dying with cancer of the breast. He explained the anemia accompanying this disease as possibly due to the changes in the gastric tubules of the stomach. In 1875, Schumann3described a case