Hypervitaminosis A

Abstract
THE clinical entity hypervitaminosis A has become more clearly understood since Josephs1 first noted the toxic effects of excessive ingestion of the vitamin. The investigations of Toomey and Morissette,2 Dickey and Bradley,3 Rothman and Leon,4 Caffey,5 Fried and Grand,6 Gribetz, Silverman and Sobel7 and Wyatt, Carabello and Fletcher8 have helped greatly in the evaluation of vitamin A toxicity in children.These investigators are in close agreement on clinical findings. Three factors are necessary for the diagnosis of hypervitaminosis A. They are: a history of excessive ingestion of the vitamin; increased vitamin A levels in the blood; and cortical hyperostoses. Other . . .

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