Toxic Proteins from Vibrio cholerae and Water Vibrios which are Lethal for Mice

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Abstract
A toxic protein has been isolated from Inaba and Ogawa strains of Vibrio cholerae and from water vibrios by dissolving the bacteria in 2-5[image]-urea and subsequent fractional precipitation with ammonium sulphate. This toxic protein accounted for the major portion of the toxicity of whole organism. Immunological and chemical data suggest that the toxic protein is the protein component of the Boivin antigen. The lipopolysaccharide endotoxins of the strains examined were relatively non-toxic as compared with the lipopolysaccharides from other Gram-negative bacteria, though in other biological and chemical properties they resembled the general class.