Methoxyphenylpolysiloxane Stationary Phases for Capillary Column Gas Chromatography

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Abstract
A series of mono-, di-, and trimethoxyphenyl-substituted polysiloxanes (30 and 50% substitution) with varying hydrocarbon spacer lengths between the polysiloxane backbone and methoxyphenyl rings were evaluated for use as stationary phases in capillary column gas chromatography. The 30% substituted stationary phases were highly efficient and stable up to 300 to 310°C, and exhibited selectivities similar to polarizable phases such as the biphenylpolysiloxanes. The 50% substituted polymers had slightly lower thermal stabilities (280 to 295°C), but showed excellent efficiencies and selectivities for alcohols, various isomers of polycyclic aromatic compounds, and antidepressant drugs. The selectivities obtained are a result of dipole-dipole interactions associated with polar solutes and polar phases, and dipole-induced-dipole interactions associated with polar solutes and polarizable phases. An increase in resolution of the isomers was obtained with an increase in the number of methoxy groups on the ring. The trimethoxyphenyl phase provided the best resolution of the isomers tested. Discussions of the effects of the position(s) and number of methoxy substituents on the phenyl ring, and of the length of the hydrocarbon spacer on various properties of the columns are included.

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