Iron, Lead, and Cobalt Absorption: Similarities and Dissimilarities

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Abstract
Using isolated intestinal segments in rats, the absorption of Fe, Pb and Co was increased in Fe deficiency and decreased in Fe loading. The absorption of these metals was decreased in transfusional erythrocytosis, after i.v. Fe injection and after parenteral endotoxin injection. Acute bleeding or abbreviated intervals of dietary Fe deprivation resulted in increased Fe absorption from isolated intestinal segments and in intact animals, while the absorption of Pb and Co was unaffected. The specificity of the mucosal metal absorptive mechanism apparently is selectively enhanced for Fe absorption by phlebotomy or brief periods of dietary Fe deprivation, or 2 or more mucosal pathways for Fe absorption may exist.

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