Response of Thymus and other Human Lymphoid Tissues to PHA, PWM and Genetically Dissimilar Lymphoid Cells.

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Abstract
Cell suspensions of human thymus, tonsil and appendix were transformed when exposed to PHA, PWM or homologous lymphoid cells in vitro. Studies suggest that in the mixed cell cultures, the transformed cells originated from both donors. Infrequently, in cultures containing transformed cells, an absence of H3[tritium]-thymidine incorporation was observed by radioautography. The response of thymus and appendiceal cells indicates that these organs do not differ in their ability to transform in response to foreign tissue.