Induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in vascular smooth muscle cells
- 3 February 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 297 (1-2) , 183-185
- https://doi.org/10.1016/0014-5793(92)80356-l
Abstract
Inducible vascular nitric oxide synthase accounts for the contractile impairment observed in ondotoxemia. We provide evidence that lipoteichoic acid (LTA) from Staphylococcus aureus, a micro‐organism without endotoxin, also induces nitric oxide synthase. Our study demonstrates that on endothelium‐free rings of rat aorta. LTA‐like lipopolysaccharide induces a loss of contractility restored by Methylene blue and N G‐nitro‐l‐arginine‐methyl ester (LNAME). Moreover in cultured vascular smooth muscle cells, LTA produces a dose‐dependent increase in intracellular cyclic GMP which is antagonized by LNAME and prevented by dexamethasone.Keywords
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