The enzyme histochemistry of metastasising basal cell carcinoma of the skin

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Abstract
A [human] case of metastasizing basal cell carcinoma of the skin is presented. The tumor was analyzed by enzyme histochemistry and cytology, and criteria are set out for establishing the diagnosis of this uncommon entity. The lesion is apparently rich in enzymes of the pentose shunt and tricarboxylic acid cycles and shows insignificant acid phosphatase activity and no activity of alkaline phosphatase. These enzyme histochemical findings are thought to be important in the differential diagnosis of various types of tumor.