EXPERIMENTAL HYPERTENSION

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Abstract
Essential hypertension in man has been compared with experimental neurogenic, renal and post-DCA hypertension as to the influence of the nervous system, the endocrine glands and kidney, and the effects of drugs and electrolyte intake. The thyroid, parathyroid and gonads appear to have little to do with any of these forms of hypertension. In contrast, the kidney and the hypophysis are involved to some degree in all. Essential hypertension is simulated most closely, in both its physiologic and anatomic characteristics, by the post-DCA syndrome. Particularly striking is the independence of these two varieties of hypertension of the presence of the adrenal gland. Results in animals corroborate and emphasize the relative failure of all known methods of clinical therapy. The experimental evidence points to the hypophysis and hypothalamus as perhaps the most promising areas for future investigations of essential hypertension.
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