THE EFFECT OF ACUTE ELEVATION OF THE PLASMA CHLORIDE CONCENTRATION ON THE RENAL EXCRETION OF BICARBONATE DURING ACUTE RESPIRATORY ACIDOSIS 1

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Abstract
Experiments performed on anesthetized dogs showed that in acute respiratory acidosis bicarbonate excretion decreased and bicarbonate reabsorption increased, whereas both chloride excretion and chloride reabsorption decreased. Also, the administration of chloride during respiratory acidosis resulted in increased bicarbonate excretion and decreased bicarbonate reabsorption. This suggests that at least part of bicarbonate reabsorption is ionic and not dependent upon pH secretion. This part of the bicarbonate reabsorption is affected by the reabsorption of chloride in such a manner as to suggest competition between chloride and bicarbonate ions for a common reabsorptive transport mechanism in the tubule.

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