LOSS OF EPITHELIAL BLOOD GROUP ANTIGEN‐A DURING WOUND HEALING IN ORAL MUCOUS MEMBRANE

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Abstract
The expression of blood group antigen A was studied on oral epithelial cells during wound healing. Twelve cases were studied, and the antigen reactivity was semiquantitated by titration in a double layer immunofluorescence staining reaction. In eight cases there was a total loss of antigen A in the migrating epithelial cells and in the sliding cells along the wound margins. In four cases there were a distinct decrease in positive reacting epithelial cells along the wound margins. The positive reacting cells all demonstrated less antigen than the cells in the non‐wounded adjacent mucosa demonstrated by a lower end point titre. The study has shown that changes in blood group antigen expression on epithelial cells during repair processes correspond to what is seen in malignant cells in oral carcinomas.