Pulsed magnetic field effects on calcium signaling in lymphocytes: Dependence on cell status and field intensity

Publisher Website
Google Scholar
Abstract
The effect of 3‐Hz, monopolar, quasi‐rectangular magnetic field pulses on 45Ca2+ uptake in resting and mitogen‐treated rat thymic lymphocytes was evaluated. A 30‐min, non‐thermal exposure to the pulsed magnetic field (B peak = 6.5 mT, E max = 0.69 mV/cm, J max = 2.6 μA/cm2) reduced Concanavalin A‐induced 45Ca2+ uptake by 45%. It was observed that (i) the induction of the 3‐Hz field response dependend on Ca2+ signal transduction activation; (ii) the response direction (stimulation or inhibition) depended on the level of lymphocyte mitogen responsiveness, and (iii) the field response magnitude increased with increasing magnetic field flux densities (B peak = 0, 1.6, 6.5 and 28 mT). Our results demonstrate field effects at B max nearly 104 greater than that of the average human environment for low‐frequency magnetic fields and they are consistent with the independent results from other 3‐Hz pulsed magnetic field studies with lymphocytes.