Novel oligosaccharides with the sialyl-Lea structure in human milk
- 19 March 1991
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 30 (11) , 2869-2876
- https://doi.org/10.1021/bi00225a020
Abstract
We have isolated four novel oligosaccharides with the sialyl-Lea structure from human milk using a monoclonal antibody, MSW 113. These oligosaccharides were purified by affinity chromatography on a column of the immobilized monoclonal antibody and by high-performance liquid chromatography. The results of structural analyses, i.e., 500-MHz 1H NMR spectroscopy, fast atom bombardment mass spectrometry, and binding to specific anticarbohydrate antibodies, are consistent with the following structures. (formula; see text)Keywords
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