Effects of Dopamine Infusion on Pituitary Hormone Secretion in Humans1

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Abstract
Dopamine, infused at a rate of 4 μ/Kg/ min for 3–4 h unaccompanied by any significant changes in cardiovascular dynamics, induced a prompt and sustained suppression of circulating prolactin (PRL) levels in normal men and women as well as in patients with hyperprolactinemia. At the discontinuation of the infusion, there was a marked rebound in PRL levels in normal subjects and a rapid return to basal levels in hyperprolactinemic patients. Dopamine infusion also induced a significant fall in LH levels in the normal subjects with a marked rebound in LH levels following the infusion. No significant changes in GH, TSH, and FSH levels were observed. These data indicate that in man a dopaminergic mechanism exists in the regulation of PRL secretion and that dopamine also exerts an inhibitory effect on LH release.

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