The effect of β‐carotene on the expression of interleukin‐6 and heme oxygenase‐1 in UV‐irradiated human skin fibroblasts in vitro
- 27 November 2001
- journal article
- Published by Wiley in FEBS Letters
- Vol. 509 (2) , 186-190
- https://doi.org/10.1016/s0014-5793(01)03169-6
Abstract
β-Carotene is discussed as an anti-oxidant micronutrient and singlet oxygen quencher in human skin, protecting against UV light-induced damage. However, we recently demonstrated that β-carotene has a pro-oxidant potential in cultured human skin fibroblasts because it enhances the UVA induction of heme oxygenase-1 (HO-1). Herein, we further show that β-carotene also strongly promotes the UVA induction of pro-inflammatory interleukin-6 (IL-6) in skin fibroblasts in vitro. Singlet oxygen quencher sodium azide abrogated up-regulation of IL-6, and likewise also of HO-1. In UVB-irradiated cells, β-carotene did not modulate levels of IL-6 and HO-1. The observed effects might be relevant for UV-induced inflammatory processesKeywords
This publication has 37 references indexed in Scilit:
- Carotenoid Supplementation Reduces Erythema in Human Skin After Simulated Solar Radiation ExposureProceedings of the Society for Experimental Biology and Medicine, 2008
- Chemiluminescent Detection and Imaging of Reactive Oxygen Species in Live Mouse Skin Exposed to UVABiochemical and Biophysical Research Communications, 2000
- Enhancement of the UVA induction of haem oxygenase‐1 expression by β‐carotene in human skin fibroblastsFEBS Letters, 1999
- Comparison of the spectral biologically effective solar ultraviolet in adjacent tree shade and sunPhysics in Medicine & Biology, 1999
- Effects of Controlled Exposure of Sunlight on Plasma and Skin Levels of β-CaroteneFree Radical Research, 1996
- UVA‐INDUCED AUTOCRINE STIMULATION OF FIBROBLAST‐DERIVED COLLAGENASE/MMP‐1 BY INTERRELATED LOOPS OFINTERLEUKIN–1 andINTERLEUKIN–6Photochemistry and Photobiology, 1994
- UVA-Induced Autocrine Stimulation of Fibroblast-Derived-Collagenase by IL-6: A Possible Mechanism in Dermal Photodamage?Journal of Investigative Dermatology, 1993
- SINGLET OXYGEN INVOLVEMENT IN THE INACTIVATION OF CULTURED HUMAN FIBROBLASTS BY UVA (334 nm, 365 nm) AND NEAR‐VISIBLE (405 nm) RADIATIONSPhotochemistry and Photobiology, 1989
- TRANSMISSION OF HUMAN EPIDERMIS AND STRATUM CORNEUM AS A FUNCTION OF THICKNESS IN THE ULTRAVIOLET AND VISIBLE WAVELENGTHSPhotochemistry and Photobiology, 1984
- ERYTHEMA AND MELANOGENESIS ACTION SPECTRA OF NORMAL HUMAN SKIN *Photochemistry and Photobiology, 1982