Dnacins, new antibiotics. I. Producing organism, fermentation, and antimicrobial activities.

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Abstract
Dnacins are new antibiotics produced by an actinomycete, strain C-14482 (N-1001). The characteristic features of the organism are: the formation of coremia on solid media, production of rod-shaped motile spores with peritrichous flagella from mature aerial mycelia, fragmentation of the mature organism (at a later stage of growth) in liquid media in which some fragmented elements have motility, lysozyme resistance, meso-diaminopimelic acid in the cell wall and a guanine-cytosine content of 71 .+-. 1 mol%. The organism was designated as Nocardia sp. C-14482 (N-1001). Dnacins show strong activity against various gram-negative, gram-positive and acid-fast bacteria but slight activity against fungi. The antibiotics hardly affect the growth of Escherichia coli K-12 under anaerobic conditions even at concentrations > 5 times that of the minimum inhibitory concentration under aerobic conditions.

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