Effect of Adrenalectomy on Wound Healing in Normal and in Stressed Rats.

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Abstract
Bilateral adrenalectomy, performed 15 days prior to laparotomy, resulted in bursting pressures equal to or superior to normal control rats. Previously it was demonstrated that stress, applied prior to laparotomy in intact rats, depresses the rate of healing. When stress (excision of 6- x 3-cm patch of skin) is induced in adrenalectomized rats, maintained on small daily dosages of adrenal cortex extract, the bursting pressure of the laparotomy wound is not depressed.