Progression and Prognosis of Chronic Myelogenous Leukemia in the Acute Stage: Hematologic and Cytogenetic Aspects

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Abstract
Patients (10) with Ph1 chromosome-positive chronic myelogenous leukemia entering the acute stage were divided hematologically into 2 different groups. One was characterized by a predominance of myeloblasts in marrow and was cytogenetic either by diploid or hypodiploid and the other had generally low myeloblast counts without significant differences between the peripheral blood and the bone marrow, and was characterized by hyperdiploidy. An extramedullary acute transformation in the spleen apparently occurs in most cases of the latter group.