Sensory abnormalities in unaffected relatives in familial adult-onset dystonia
- 27 September 2005
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 65 (6) , 938-940
- https://doi.org/10.1212/01.wnl.0000176068.23983.a8
Abstract
Somatosensory abnormalities are found in adult-onset primary torsion dystonia (PTD). Therefore we assessed spatial discrimination thresholds (SDT), a measure of spatial acuity, in four multiplex families with adult-onset PTD. In family members aged 20 to 45 years vs controls (mean + 2.5 SD), abnormal SDTs were found in four of five affected with adult-onset PTD and in 12 of 49 unaffected relatives. Sensory abnormalities may be an endophenotype, possibly expressed later as adult-onset PTD.Keywords
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