CARDIOMYOPATHY PRODUCED BY CIGARETTE-SMOKE - ULTRASTRUCTURAL OBSERVATIONS IN GUINEA-PIGS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 102  (7) , 377-380
Abstract
Guinea pigs were restrained in a smoking machine and were exposed to the smoke of 8 cigarettes/day, 5 days/wk for 12-15 wk. One group of animals inhaled filtered smoke from which most of the tar and nicotine was removed. Heart weight of the smoking animals was significantly increased in both the filtered and unfiltered groups. Toxic changes were evident in myocardial mitochondria that were associated with edema, increased lipid and enhanced autophagolysosomal activity. The cardiomyopathy observed was probably caused by CO and resembled the changes of chronic intermittent hypoxia.

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