Effect of valpromide on the pharmacokinetics of carbamazepine‐10, 11‐ epoxide.
Open Access
- 1 May 1988
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 25 (5) , 611-613
- https://doi.org/10.1111/j.1365-2125.1988.tb03354.x
Abstract
The single oral dose pharmacokinetics of carbamazepine-10, 11-epoxide (CBZ-E) were investigated in six normal volunteers during a control session and during concurrent treatment with valpromide (VPM) (300 mg twice daily for 8 days). VPM caused a prolongation of the CBZ-E half- life from 6.4 +/- 1.4 to 20.5 +/- 6.3 h and decreased CBZ-E clearance from 73.5 +/- 20.0 to 23.5 +/- 4.0 ml h-1 kg-1 (P less than 0.01). These results suggest that the elevation of plasma CBZ-E levels in patients receiving carbamazepine and VPM in combination is due to inhibition of epoxide hydrolase in the liver.This publication has 13 references indexed in Scilit:
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