Pharmacokinetic prediction of tissue residues
- 1 March 1977
- journal article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 2 (4) , 735-756
- https://doi.org/10.1080/15287397709529477
Abstract
The applications of pharmacokinetic modeling to the prediction of tissue residues of drugs in food-producing animals are reviewed. The properties of the one-compartment open model are discussed, and the application of this model to the serum levels, urine outputs, and tissue residues of sulfamethazine and its metabolites in sheep is described. The properties of the two-compartment model are discussed, and the application of this model to the serum levels and urine outputs of dicloxacillin in humans is described. Complexities encountered with drugs such as pentobarbital, the tetracyclines, etidronate, and salicylate are discussed as examples of pharmacokinetic behavior that make both modeling and tissue residue prediction difficult.Keywords
This publication has 7 references indexed in Scilit:
- The role of the kidney in the elimination of cephapirin in manJournal of Pharmacokinetics and Biopharmaceutics, 1975
- Statistical estimations in pharmacokineticsJournal of Pharmacokinetics and Biopharmaceutics, 1974
- Pharmacokinetics of pentobarbital after intravenous and oral administrationJournal of Pharmacokinetics and Biopharmaceutics, 1973
- Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog and monkeyToxicology and Applied Pharmacology, 1972
- Influence of repetitive dosing of tetracyclines on biologic half‐life in serumClinical Pharmacology & Therapeutics, 1969
- Kanamycin Dosage and Levels in Ear and Other OrgansJAMA Otolaryngology–Head & Neck Surgery, 1967
- Pharmacokinetics of Salicylate Elimination in ManJournal of Pharmaceutical Sciences, 1965