The LD50 test
- 13 March 1983
- journal article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 52 (s2) , 6-19
- https://doi.org/10.1111/j.1600-0773.1983.tb02680.x
Abstract
The nature of the LD50 test and its central place in the conceptual development or pharmacology is reviewed. The results of the test and possible uses are outlined. Some guidelines are set out for the development of alternatives to LD50 tests. Some circumstances are suggested in which it seems likely that some form of the test will continue to be required. It is concluded that the problem of replacing the LD50 test with apparently more elegant methods is part of the larger and more fundamental problem of bringing science to the study and regulation of toxicology.Keywords
This publication has 4 references indexed in Scilit:
- Significance of the LD50-test for the toxicological evaluation of chemical substancesArchives of Toxicology, 1981
- The Ethics of VivisectionTheology, 1975
- The error of determination of toxicityProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1927