A Macroscopic Agglutination Test with Typhus Rickettsiae Prepared from Infected Rodent Lungs

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Abstract
Rickettsiae of Mexican typhus, prepd. in large amts. and in pure state from infected lungs of white rats and mice, were employed as antigen in a macroscopic test for agglutinins to rickettsiae. The antigen was clumped in significant dilutions of serum by the sera of the 5 persons ill and convalescent from Mexican typhus, and by the sera of laboratory animals (rabbit, horse, guinea-pig) experimentally infected or immunized by the same virus. The sera of normal animals and of persons in Ohio did not agglutinate rickettsiae. The sera of persons vaccinated againust Mexican typhus gave various results. This survey indicates the possibility of using the agglutination test as an aid in typhus research, by the limitations and extent of application of the test are yet to be detd.

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