A comparison in germ‐free mice of the pathogenesis of Sendai virus and mouse pneumonia virus infections

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Abstract
The pathogenesis of Sendai virus and pneumonia virus of mice (PVM) was studied using the immunoperoxidase technique on paraffin lung sections. The pathology of Sendai virus corresponds to that of a bronchopneumonia with virus demonstrated by immunoperoxidase in the bronchial epithelium and sometimes in macrophages for 2-9 days post-infection. PVM produces an interstitial pneumonia with virus demonstrated in the bronchial epithelium and in the alveolar walls and alveolar macrophages. This virus can be demonstrated 2-7 days post-infection. This technique was used to demonstrate PVM in the case of a natural outbreak of this disease and may eventually become a routine technique for the screening of lung tissue for respiratory viruses.
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