ALTERNATIVE BIOASSAYS OF KINSHIP BETWEEN LOCI

  • 1 January 1988
    • journal article
    • research article
    • Vol. 42  (1) , 173-177
Abstract
In this study four asymptotically equivalent estimates of kinship are derived, in the general case and for kinship between multiallelic loci. Two estimates based on x2 agree closely, with the Shannon estimate giving the smaller variance. The PAH, GH, GM, and HBB systems conform to a recombinational model with an evoluntionary size of .apprx. 4,000 and a ratio of recombination to physical distance of .apprx. 1.4 .times. 10-5 morgans/kb, as predicted on the basis of the genetic and physical lengths of the human genome. The INS and D11S12 systems have a much more rapid decline of kinship with physical distance, suggesting overlapping RFLPs (unrecognized allelism), recombinational hot spots, or selection. Sources of error in predicting kinship over small distances are discussed.