Interaction of Cocaine and G-Strophanthin on the Membrane Potential of Frog Sartorius Muscle Fibres
- 1 January 1963
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 8 (4-6) , 242-250
- https://doi.org/10.1159/000135309
Abstract
The depolarizing action of G-strophanthin on the frog muscle membrane can be reduced by cocaine. Furthermore, in the presence of cocaine it is much easier to reverse the G-strophanthin depolarization by washing with drug-free Ringer''s solution. It is suggested that the cocaine prevents Ca ions from being available to the strophanthin molecule at the site of action and hence the glycoside cannot effectively be bound to the site of action.Keywords
This publication has 1 reference indexed in Scilit:
- Movement of Inorganic Ions across the Membrane of Striated MuscleCirculation, 1962