Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue
Top Cited Papers
- 21 December 2001
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 294 (5551) , 2542-2545
- https://doi.org/10.1126/science.1066707
Abstract
Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing daughter cells that either self-renew or initiate differentiation. Although the surrounding microenvironment or “niche” influences stem cell fate decisions, few signals that emanate from the niche to specify stem cell self-renewal have been identified. Here we demonstrate that the apical hub cells in the Drosophila testis act as a cellular niche that supports stem cell self-renewal. Hub cells express the ligand Unpaired (Upd), which activates the Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway in adjacent germ cells to specify self-renewal and continual maintenance of the germ line stem cell population.Keywords
This publication has 21 references indexed in Scilit:
- Control of Stem Cell Self-Renewal in Drosophila Spermatogenesis by JAK-STAT SignalingScience, 2001
- A Niche Maintaining Germ Line Stem Cells in the Drosophila OvaryScience, 2000
- Somatic control over the germline stem cell lineage during Drosophila spermatogenesisNature, 2000
- GFP-tagged balancer chromosomes for Drosophila melanogasterMechanisms of Development, 1999
- The Drosophila Jak Kinase Hopscotch Is Required for Multiple Developmental Processes in the EyeDevelopmental Biology, 1999
- Specific Contribution of Tyk2 JH Regions to the Binding and the Expression of the Interferon α/β Receptor Component IFNAR1Journal of Biological Chemistry, 1998
- Regulatory Mechanisms in Stem Cell BiologyCell, 1997
- marelle Acts Downstream of the Drosophila HOP/JAK Kinase and Encodes a Protein Similar to the Mammalian STATsCell, 1996
- Spermatogenesis following male germ-cell transplantation.Proceedings of the National Academy of Sciences, 1994
- The germinal proliferation center in the testis of Drosophila melanogasterJournal of Ultrastructure Research, 1979