CLINICAL STUDIES IN GERIATRICS

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Abstract
EXISTING knowledge concerned with the change of cellular metabolism associated with aging is limited. Available information on the relation of lipid metabolism to the aging process is also limited and has been the basis for considerable theoretical speculation. It has however latterly become understood that physiologic aging has no real relationship with such degenerative changes as atherosclerosis, which are associated with abnormalities of lipid metabolism. The hard calcified arteries of old age may show little if any of the focal intimal lesions termed atheroma, while the early fatty flecks of these lesions can be found in the soft flexible arteries of youth. Atheromata are selectively localized accumulations of cholesterol, cholesterol esters, and other lipid deposits in the arterial intima, causing intimal fibrous thickening. Atherosclerosis is primarily a disease of the intimal coat, and the important clinical consequence is interference with blood flow to essential organs. This is to be differentiated

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