PHYSIOLOGICAL AND PHARMACOLOGICAL STUDIES ON ISOLATED HUMAN BRONCHIAL PREPARATIONS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 59  (2) , 66-74
Abstract
The contractile response of human bronchial smooth muscle preparations obtained after death (necrobronchi) from 15 patients was studied in vitro. Reproduceable responses sufficient for calculating dose-response curves, could be obtained up to 30 h after death. The smooth muscle stimulants investigated were carbacholine, acetylcholine, histamine and electrical field stimulation. In addition to these bronchial smooth muscle relaxants such as adrenaline [epinephrine], salbutamol and terbutaline were also studied. These agents showed a dose-dependent relaxation in preparations previously treated with carbacholine. Apparently in vitro testing of smooth muscle preparations obtained from human cadavers is possible.

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