The Conjugation of 4-Chloro- and 4-Nitro-phenylacetic Acids in Man, Monkey and Rat

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Abstract
1. The conjugation of 4-chloro- and 4-nitro-phenylacetic acid in man, rhesus monkey, capuchin monkey and the rat has been investigated. 2. The four species excreted up to 95% of the radioactivity from an oral or injected dose of [14C]-4-chlorophenylacetic acid in the urine in 24 h. The major conjugate in the urine of a human subject after oral dosing, and the rhesus and capuchin monkeys after intramuscular injection, was 4-chlorophenacetyl-glutamine. The two monkeys, but not man, excreted also small amounts (et al., 1972). 4. [14C]-4-Nitrophenylacetic acid was rapidly excreted in the urine (90% dose in 24 h) by humans (after oral administration), and by rhesus monkeys and rats (after intraperitoneal injection). Man and the rhesus monkey excreted most (about 80% dose) of the acid unchanged together with small amounts (5–8% dose) of an unidentified metabolite which gave 4-nitrophenylacetic acid on acid hydrolysis. The rat, however, excreted 61% of the dose as 4-nitrophenacetylglycine and 28% unchanged.

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