Enkephalins co-exist with oxytocin and vasopressin in nerve terminals of rat neurohypophysis
- 1 February 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 289 (5797) , 502-504
- https://doi.org/10.1038/289502a0
Abstract
Evidently opiates inhibit the release of oxytocin and vasopressin by acting on nerve terminals in the neurohypophysis. Extracts of neurohypophysis contain substantial amounts of Met- and Leu-enkephalin, and Leu-enkephalin-immunoreactive (IR) nerve fibers originating in the magnocellular hypothalamic nuclei were described in the neural lobe, where the 2 hormones are secreted. The distributions of oxytocin, vasopressin and enkephalin immunoreactivity (IR) in the neurohypophysis of the rat were compared; Met-enkephalin-IR is invariably associated with nerve terminals that contain oxytocin-IR whereas the terminals that contain vasopressin-IR often, but not invariably, are Leu-enkephalin immunoreactive.This publication has 14 references indexed in Scilit:
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