The Effect of Sustained Hyperammonemia upon the Metabolic State of the Brain
- 1 January 1972
- journal article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 30 (3) , 245-255
- https://doi.org/10.3109/00365517209084286
Abstract
The effects of sustained hyperammonemia upon the cerebral energy state and upon extra- and intracellular acid-base parameters were evaluated in lightly anesthetized normocapnic rats. The hyperammonemia was associated with decreased pools of labile phosphates (PCr and ATP) in spite of unchanged intracellular pH, thus indicating an unbalanced energy metabolism. A functional depletion of α-ketoglutarate is discussed as a possible mechanism.Keywords
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