The stochastic behavior of a molecular switching circuit with feedback
Open Access
- 1 January 2007
- journal article
- Published by Springer Nature in Biology Direct
- Vol. 2 (1) , 13
- https://doi.org/10.1186/1745-6150-2-13
Abstract
Using a statistical physics approach, we study the stochastic switching behavior of a model circuit of multisite phosphorylation and dephosphorylation with feedback. The circuit consists of a kinase and phosphatase acting on multiple sites of a substrate that, contingent on its modification state, catalyzes its own phosphorylation and, in a symmetric scenario, dephosphorylation. The symmetric case is viewed as a cartoon of conflicting feedback that could result from antagonistic pathways impinging on the state of a shared component.Keywords
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