PARENTERAL IMMUNIZATION OF PIGS AGAINST INFECTION WITH TREPONEMA-HYODYSENTERIAE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 39  (4) , 639-642
Abstract
Six i.v. injections of formalin-inactivated T. hyodysenteriae were given to 8 specific-pathogen-free pigs at 6-day intervals. The 8 vaccinated and 8 control pigs were challenged intragastrically with pure cultures of T. hyodysenteriae 7 and 8 days after the last i.v. injection. Clinical signs of swine dysentery were observed in all 8 control pigs, but was observed in only 1 of the immunized pigs. Three control pigs died. These findings suggest that parenteral immunization with T. hyodysenteriae provided a marked degree of protection against subsequent intragastric challenge exposure with the homologous isolate of T. hyodysenteriae.

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