A Comparison of the Defleecing Action of Cyclophosphamide in Four Breeds of Sheep1

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Abstract
A total of 88 purebred yearling Dorset, Hampshire, Suffolk and Targhee rams and ewes were randomized within breed and sex to 9.1 or 12.2 mg of cyclophosphamide (CPA) per pound of body weight (20.0 or 27.0 mg/kg). The drug was given once, in freshly prepared aqueous solution, by stomach tube. The objective was to determine whether these breeds differ in their defleecing response to CPA. The degree of wool loosening was assessed subjectively by a scoring system on days 6 and 8 after CPA treatment. The loosened wool was not manually removed, but was permitted to come off as it would in the course of the sheep's activities. The percentage of area from which wool had been lost from five contiguous locations on the body was estimated by visual inspection on day 13 after CPA treatment, and wool regrowth was measured on the shoulder 39 days after CPA treatment. The response to CA was affected by sex, CPA dosage, the particular location of the wool on the sheep and days after CPA treatment in a manner generally similar to previous observations, but no differences were observed among the four breeds that would require a different management system for chemical defleecing for one breed relative to any of the others. Copyright © 1976. American Society of Animal Science . Copyright 1976 by American Society of Animal Science.

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