Isolation of an Intertypic Poliovirus Capsid Recombinant from a Child with Vaccine-Associated Paralytic Poliomyelitis
Open Access
- 1 November 2002
- journal article
- case report
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (21) , 10921-10928
- https://doi.org/10.1128/jvi.76.21.10921-10928.2002
Abstract
The isolation of a capsid intertypic poliovirus recombinant from a child with vaccine-associated paralytic poliomyelitis is described. Virus 31043 had a Sabin-derived type 3-type 2-type 1 recombinant genome with a 5′-end crossover point within the capsid coding region. The result was a poliovirus chimera containing the entire coding sequence for antigenic site 3a derived from the Sabin type 2 strain. The recombinant virus showed altered antigenic properties but did not acquire type 2 antigenic characteristics. The significance of the presence in nature of such poliovirus chimeras and the consequences for the current efforts to detect potentially dangerous vaccine-derived poliovirus strains are discussed in the context of the global polio eradication initiative.Keywords
This publication has 69 references indexed in Scilit:
- Genomic Features of Intertypic Recombinant Sabin Poliovirus Strains Excreted by Primary VaccineesJournal of Virology, 2001
- Circulation of a Type 2 Vaccine-Derived Poliovirus--Egypt, 1982-1993Published by American Medical Association (AMA) ,2001
- The Vaccine Origin of the 1968 Epidemic of Type 3 Poliomyelitis in PolandVirology, 2000
- Tripartite genome organization of a natural type 2 vaccine/nonvaccine recombinant poliovirusJournal of General Virology, 1995
- Characterization of three different transgenic mouse lines that carry human poliovirus receptor gene?influence of the transgene expression on pathogenesisArchiv für die gesamte Virusforschung, 1994
- Antigenic structure of chimeras of type 1 and type 3 polioviruses involving antigenic sites 2, 3 and 4Journal of General Virology, 1991
- Antigenic structure of chimeras of type 1 and type 3 poliovirus involving antigenic site 1Journal of General Virology, 1990
- New model for the secondary structure of the 5′ non-coding RNA of poliovirus is supported by biochemical and genetic data that also show that RNA secondary structure is important in neurovirulenceJournal of Molecular Biology, 1989
- Genetic stability of poliovirus insertion mutants with a foreign oligopeptide on the capsid surfaceResearch in Virology, 1989
- Antigenic and Molecular Evolution of the Vaccine Strain of Type 3 Poliovirus during the Period of Excretion by a Primary VaccineeJournal of General Virology, 1986